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KMID : 0604520180440040419
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 4 p.419 ~ p.425
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Analysis of Procollagen Biosynthesis of Functional Peptides Utilizing Stiffness Controlled Artificial Skin Dermis
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Byun Jin-A
Shin Sung-Gyu
Han Sa-Ra
Cho Sung-Woo
Lim Jun-Woo
Jeong Jae-Hyun
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Abstract
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In this study, cross-linked collagen gels were successfully prepared with varying of elastic modulus from 0.7 to 17.7 kPa using a chemical cross-linker. Then, human dermal fibroblasts were encapsulated into the porous pores introduced into the gels, and cell growth and behavior were examined by gel’s mechanical properties. Specifically, increasing elastic modulus of the gel led to decreases in procollagen synthesis from 47 to 32 ng. In addition, there could be optimum elastic modulus for procollagen production, when the gels were treated with adenosine. However, interestingly, this study discovered that the procollagen production level was not influenced by the elastic modulus of the gel for functional peptide. In conclusion, these results would be highly useful for designing reconstructed skins with varying of elastic modulus to examine functional materials in cosmetics.
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KEYWORD
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collagen gel, glutaraldehyde, elastic modulus, functional peptide, pro-collagen
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